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1

Mathematical modeling of tumor growth and tumor growth inhibition in oncology drug development

Bernard, Apexa, Kimko, Holly, Mital, Dinesh, Poggesi, Italo

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2012

Language:

english

File:

PDF, 483 KB

english, 2012

2

Impact of low percentage of data below the quantification limit on parameter estimates of pharmacokinetic models

Xu Steven Xu, Adrian Dunne, Holly Kimko, Partha Nandy, An Vermeulen

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2011

Language:

english

File:

PDF, 302 KB

english, 2011

3

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 ||

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 13.38 MB

english, 2016

4

Improving Realism in Clinical Trial Simulations via Real-World Data

Kimko, Holly, Lee, Kwan

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2017

Language:

english

File:

PDF, 193 KB

english, 2017

5

[AAPS Advances in the Pharmaceutical Sciences Series] Clinical Trial Simulations Volume 1 || Balancing Efficacy and Safety in the Clinical Development of an Atypical Antipsychotic, Paliperidone Extended-Release

Kimko, Holly H. C., Peck, Carl C.

Year:

2011

Language:

english

File:

PDF, 426 KB

english, 2011

6

Population pharmacodynamic modeling of various extended-release formulations of methylphenidate in children with attention deficit hyperactivity disorder via meta-analysis

Holly Kimko, Ekaterina Gibiansky, Leonid Gibiansky, H. Lynn Starr, Joris Berwaerts, Joseph Massarella, Frank Wiegand

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2012

Language:

english

File:

PDF, 480 KB

english, 2012

7

[AAPS Advances in the Pharmaceutical Sciences Series] Clinical Trial Simulations Volume 1 || Recent Developments in Physiologically Based Pharmacokinetic Modeling

Kimko, Holly H. C., Peck, Carl C.

Year:

2011

Language:

english

File:

PDF, 266 KB

english, 2011

8

[AAPS Advances in the Pharmaceutical Sciences Series] Clinical Trial Simulations Volume 1 || The Application of Drug-Disease Models in the Development of Anti-Hyperglycemic Agents

Kimko, Holly H. C., Peck, Carl C.

Year:

2011

Language:

english

File:

PDF, 464 KB

english, 2011

9

A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia

Marin H Kollef, Jean Chastre, Marc Clavel, Marcos I Restrepo, Bart Michiels, Koné Kaniga, Iolanda Cirillo, Holly Kimko, Rebecca Redman

Journal:

Critical Care (BioMed Central)

Year:

2012

Language:

english

File:

PDF, 645 KB

english, 2012

10

[AAPS Advances in the Pharmaceutical Sciences Series] Clinical Trial Simulations Volume 1 || Application of Pharmacokinetic–Pharmacodynamic Modeling and Simulation for Erythropoietic Stimulating Agents

Kimko, Holly H. C., Peck, Carl C.

Year:

2011

Language:

english

File:

PDF, 282 KB

english, 2011

11

[AAPS Advances in the Pharmaceutical Sciences Series] Clinical Trial Simulations Volume 1 || A Model-Based PK/PD Antimicrobial Chemotherapy Drug Development Platform to Simultaneously Combat Infectious Diseases and Drug Resistance

Kimko, Holly H. C., Peck, Carl C.

Year:

2011

Language:

english

File:

PDF, 639 KB

english, 2011

12

Population Pharmacokinetics of Rabeprazole and Dosing Recommendations for the Treatment of Gastroesophageal Reflux Disease in Children Aged 1–11 Years

McLeay, Sarah C., Green, Bruce, Treem, William, Thyssen, An, Mannaert, Erik, Kimko, Holly

Journal:

Clinical Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

13

Model-based clinical drug development in the past, present and future: a commentary

Kimko, Holly, Pinheiro, José

Journal:

British Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 685 KB

english, 2015

14

[AAPS Advances in the Pharmaceutical Sciences Series] Clinical Trial Simulations Volume 1 ||

Kimko, Holly H. C., Peck, Carl C.

Year:

2011

Language:

english

File:

PDF, 10.22 MB

english, 2011

15

Helicobacter pylori treatment in children: Defining a dose for rabeprazole as a part of a triple therapy regimen

Kimko, Holly, Thyssen, An, Mould, Diane R., Mannaert, Erik, Treem, William R.

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

16

[AAPS Advances in the Pharmaceutical Sciences Series] Clinical Trial Simulations Volume 1 || PKPD and Disease Modeling: Concepts and Applications to Oncology

Kimko, Holly H. C., Peck, Carl C.

Year:

2011

Language:

english

File:

PDF, 833 KB

english, 2011

17

Osteoarthritis disease progression model using six year follow-up data from the osteoarthritis initiative

Passey, Chaitali, Kimko, Holly, Nandy, Partha, Kagan, Leonid

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 260 KB

english, 2015

18

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Mechanistic Models of Physiological Control Systems

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 793 KB

english, 2016

19

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Detecting Pharmacokinetic and Pharmacodynamic Covariates from High-Dimensional Data

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 537 KB

english, 2016

20

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Kinetic Models of Biochemical Signaling Networks

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 377 KB

english, 2016

21

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Using Systems Pharmacology to Advance Oncology Drug Development

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 594 KB

english, 2016

22

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 424 KB

english, 2016

23

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Nonlinear Mixed Effects Modeling in Systems Pharmacology

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 427 KB

english, 2016

24

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Discrete Dynamic Modeling: A Network Approach for Systems Pharmacology

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 505 KB

english, 2016

25

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 1.68 MB

english, 2016

26

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Systems Pharmacology and Pharmacodynamics: An Introduction

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 153 KB

english, 2016

27

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Systems Pharmacology Modeling in Type 2 Diabetes Mellitus

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 1.22 MB

english, 2016

28

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Multi-scale Modeling of Drug Action in the Nervous System

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 456 KB

english, 2016

29

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Foundations of Pharmacodynamic Systems Analysis

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 775 KB

english, 2016

30

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Irreversible Pharmacodynamics

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 370 KB

english, 2016

31

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Quantitative Systems Pharmacology: Applications and Adoption in Drug Development

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 518 KB

english, 2016

32

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Role of Systems Modeling in Regulatory Drug Approval

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 142 KB

english, 2016

33

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Mechanistic Modeling of Inflammation

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 578 KB

english, 2016

34

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Direct, Indirect, and Signal Transduction Response Modeling

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016

35

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Translational Modeling of Antibacterial Agents

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 562 KB

english, 2016

36

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Feedback Control Indirect Response Models

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 702 KB

english, 2016

37

[AAPS Advances in the Pharmaceutical Sciences Series] Systems Pharmacology and Pharmacodynamics Volume 23 || Systems Pharmacology: An Overview

Mager, Donald E., Kimko, Holly H.C.

Year:

2016

Language:

english

File:

PDF, 711 KB

english, 2016

38

Use of statistical and pharmacokinetic–pharmacodynamic modeling and simulation to improve decision-making: A section summary report of the trends and innovations in clinical trial statistics conference

Kimko, Holly, Berry, Seth, O’Kelly, Michael, Mehrotra, Nitin, Hutmacher, Matthew, Sethuraman, Venkat

Journal:

Journal of Biopharmaceutical Statistics

Year:

2017

Language:

english

File:

PDF, 1.40 MB

english, 2017

39

A Viral Dynamic Model for Treatment Regimens with Direct-acting Antivirals for Chronic Hepatitis C Infection

Adiwijaya, Bambang S., Kieffer, Tara L., Henshaw, Joshua, Eisenhauer, Karen, Kimko, Holly, Alam, John J., Kauffman, Robert S., Garg, Varun, Kosakovsky Pond, Sergei L.

Journal:

PLoS Computational Biology

Year:

2012

Language:

english

File:

PDF, 741 KB

english, 2012

40

Toward Dynamic Prescribing Information: Codevelopment of Companion Model-Informed Precision Dosing Tools in Drug Development

Polasek, Thomas M., Rayner, Craig R., Peck, Richard W., Rowland, Andrew, Kimko, Holly, Rostami-Hodjegan, Amin

Journal:

Clinical Pharmacology in Drug Development

Year:

2018

Language:

english

File:

PDF, 158 KB

english, 2018

41

Assumption Checking Before Application of the Prespecified QT Linear Mixed Effect Model is Essential

RekiÄ, Dinko, Parkinson, Joanna, Kimko, Holly

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2020

File:

PDF, 1.33 MB

2020